When Lufthansa changes your flight schedule — whether due to operational requirements or unforeseen events — and you’re no longer able to travel, you’re generally eligible for a full refund. This is true even for non-refundable fares. You must act promptly and notify the airline or your travel agency that the new schedule doesn’t suit your plans.
https://ideaexpress.us/how-to-cancel-lufthansa-airlines-business-class-tickets-and-get-a-refund/
How to Cancel Lufthansa Airlines Business Class Tickets and Get a Refund